DNA THERAPEUTICS
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Due to technology confidentiality and patent applications, the publication of the princeps article describing Dbait molecules, their mechanisms of action (MoA) and proofs of concept (PoC) was held until early 2009:

Small-Molecular Drugs Mimicking DNA Damage: A New Strategy for Sensitizing Tumors to Radiotherapy

Maria Quanz, Nathalie Berthault, Christophe Roulin, Maryline Roy, Aurélie Herbette, Céline Agrario, Christophe Alberti, Véronique Josserand, Jean-Luc Coll, Xavier Sastre-Garau, Jean-Marc Cosset, Lionel Larue, Jian-Sheng Sun and Marie Dutreix

Clinical Cancer Research 15:1308, February 15, 2009.


Hyperactivation of DNA-PK by double-strand break mimicking molecules disorganizes DNA damage response

Maria Quanz, Danielle Chassoux, Nathalie Berthault, Céline Agrario, Jian-Sheng Sun and Marie Dutreix

PLoS ONE 4:e6298, July 21, 2009.


Molecular therapy in support to radiotherapy

Marie Dutreix, Jean-Marc Cosset and Jian-Sheng Sun

Mutat. Res.: Rev. Mutat. Res. January 11, 2010, doi:10.1016/j.mrrev.2010.01.001








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